LAMC2 : laminin subunit gamma 2

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Description

The LAMC2 (laminin subunit gamma 2) is a protein-coding gene located on chromosome 1.

The LAMC2 gene provides instructions for making the gamma subunit of the laminin 332 protein. This protein, composed of alpha, beta, and gamma subunits, regulates cell growth, movement, and adhesion. Laminins contribute to the formation of basement membranes, which are essential for tissue support and separation. Laminin 332 specifically plays a key role in the basement membrane of the epidermis, providing strength and resilience, and acting as a barrier between the body and its environment. This laminin is also important for wound healing and has been implicated in corneal development and tooth enamel formation.

Laminin, a complex protein that LAMC2 contributes to, plays a crucial role in cell attachment, migration, and organization during embryonic development. It interacts with other components of the extracellular matrix, acting as a mediator for these processes. LAMC2's subunit (gamma-2) is also known as Ladsin, which exhibits cell-scattering activity across various cell types, including epithelial, endothelial, and fibroblast cells.

LAMC2 is also known as B2T, BM600, CSF, EBR2, EBR2A, JEB3A, JEB3B, LAMB2T, LAMNB2.

Associated Diseases

• Intermediate generalized junctional epidermolysis bullosa
• Epidermolysis bullosa, junctional, Herlitz type
• Epidermolysis bullosa, junctional 3B, severe
• Epidermolysis bullosa, junctional 3A, intermediate
• Severe generalized junctional epidermolysis bullosa
• Junctional epidermolysis bullosa