LAMA3 : laminin subunit alpha 3
Description
The LAMA3 (laminin subunit alpha 3) is a protein-coding gene located on chromosome 18.
The LAMA3 gene provides instructions for making the alpha subunit of laminin 332, a protein vital for cell growth, movement, and adhesion. It's also crucial for forming and organizing basement membranes, which support cells in various tissues. Laminin 332 is particularly important in the skin's basement membrane, providing strength and creating a barrier between the body and its environment. It's also involved in wound healing and may play a role in cornea development and tooth enamel formation. The alpha subunit produced by LAMA3 is also part of laminin 311 and 321, which contribute to skin strength but are less significant than laminin 332. Laminin 311 is also involved in cell signaling in the lungs and other tissues.
Laminin, a complex glycoprotein comprised of three polypeptide chains, plays a crucial role in embryonic development by facilitating cell attachment, migration, and organization into tissues. It achieves this by interacting with other components of the extracellular matrix and binding to cells through a high-affinity receptor.
LAMA3 is also known as BM600, E170, JEB2A, JEB2B, JEB2C, LAMNA, LOCS.
Associated Diseases
- Severe generalized junctional epidermolysis bullosa
- Laryngoonychocutaneous syndrome
- Epidermolysis bullosa, junctional, Herlitz type
- Epidermolysis bullosa, junctional 2A, intermediate
- Epidermolysis bullosa, junctional 2B, severe
- Intermediate generalized junctional epidermolysis bullosa
- Junctional epidermolysis bullosa
- Laryngo-onycho-cutaneous syndrome
