KRT83 : keratin 83

Description

The KRT83 gene, encodes keratin 83, a type I cytokeratin protein crucial for the structural integrity of the skin. It forms intermediate filaments within keratinocytes, the major cell type of the epidermis, providing resilience and flexibility to the skin. KRT83 plays a role in cell adhesion, differentiation, and wound healing. Mutations in this gene can lead to various skin disorders, highlighting its importance in maintaining skin health.

Associated Diseases

• Epidermolytic hyperkeratosis (EHK)
• Palmoplantar keratoderma (PPK)
• Ichthyosis
• Keratosis pilaris
• Nail dystrophy

Did you know?

Keratin 83, along with other keratins, is responsible for the unique texture and strength of human hair, nails, and skin.