KRT14 : keratin 14
Description
KRT14, the gene encoding keratin 14, is a vital component of the skin‘s structural framework. It forms an intricate network with other keratins, primarily keratin 1, to create the tough and resilient layer of the epidermis called the basal layer. This layer serves as the foundation for new skin cells and acts as a protective barrier against external threats. KRT14‘s crucial role in maintaining skin integrity highlights its importance in skin development, wound healing, and overall skin health.
Associated Diseases
- Epidermolysis Bullosa Simplex (EBS): A group of genetic disorders characterized by blistering and fragility of the skin caused by mutations in KRT14 or KRT1 genes.
- Ichthyosis: A group of skin disorders characterized by dry, scaly, and thickened skin. Mutations in KRT14 can contribute to some forms of ichthyosis.
- Palmoplantar Keratoderma: A skin condition that causes thickening and hyperkeratosis of the palms and soles. Some types of palmoplantar keratoderma are associated with KRT14 mutations.
Did you know?
KRT14 is expressed not only in the skin but also in other epithelial tissues like hair follicles and the cornea, showcasing its broader role in maintaining epithelial integrity.
