KLK4
Description
The KLK4 gene, located on chromosome 19, encodes a serine protease known as kallikrein-related peptidase 4. KLK4 is predominantly expressed in prostate tissue, where it plays a vital role in the complex process of prostate development and function. Its activity is intricately linked to the regulation of prostate epithelial cell growth, differentiation, and apoptosis. Furthermore, KLK4‘s involvement in extracellular matrix remodeling suggests a wider role in cellular communication and tissue homeostasis. However, aberrant KLK4 expression and activity have been strongly implicated in the development and progression of prostate cancer, making it a promising target for diagnostic and therapeutic strategies.
Associated Diseases
Did you know?
KLK4 has been shown to be highly sensitive to androgen levels, making it a potential target for therapies that aim to block androgen signaling in prostate cancer.
