KISS1R

Description

The KISS1R gene, encoding the kisspeptin receptor, plays a crucial role in the intricate regulation of reproductive function. This G protein-coupled receptor is activated by kisspeptin, a peptide hormone, triggering a cascade of events that ultimately control the release of gonadotropin-releasing hormone (GnRH). This intricate interplay ensures the proper timing and function of puberty, ovulation, and fertility. However, the influence of KISS1R extends beyond reproduction, impacting metabolism, energy homeostasis, and even tumor growth. Understanding the multifaceted role of KISS1R holds significant promise for addressing various health challenges.

Associated Diseases

• Hypogonadotropic Hypogonadism (HH)
• Infertility
• Premature Puberty
• Polycystic Ovary Syndrome (PCOS)
• Obesity
• Cancer (e.g., breast, prostate, ovarian)

Did you know?

KISS1R was initially discovered in a study investigating genes involved in cancer, highlighting its complex and multifaceted role in the body.