KIF3B
Description
The KIF3B (kinesin family member 3B) is a protein-coding gene located on chromosome 20.
KIF3B is a protein encoded by the KIF3B gene in humans. It belongs to the Kinesin-2 family and forms two-headed anterograde motors with two other kinesin proteins. First, KIF3B forms a heterodimer with KIF3A, which is membrane-bound and has ATPase activity. Then, KIFAP3 binds to the tail domain to form a heterotrimeric motor. This motor exhibits plus end-directed microtubule sliding activity with a velocity of ~0.3 μm/s. The expression of the three motor subunits is ubiquitous, and the KIG3A/3B/KAP3 motors can transport organelles ranging from 90 to 160 nm in diameter. KIF3B has orthologous genes in various species, including Drosophila, sea urchin, cattle, dog, horse, cat, monkey, mouse, chimpanzee, and rat. The KIF3B/KIF3A/KAP3 motor machinery is involved in intracellular transport of molecules like β-catenin and MT1-MMP. KIF3B activity has been linked to various cellular processes such as intracellular movement of organelles, intraflagellar transport, chromosome movement during mitosis and meiosis, and cellular interaction with the extracellular matrix.
KIF3B is a microtubule-based molecular motor that transports intracellular cargos, including vesicles, organelles, and protein complexes. It uses ATP hydrolysis to generate force for binding and movement along microtubules. KIF3B plays a role in cilia formation and is involved in photoreceptor integrity and opsin trafficking in rod photoreceptors. KIF3B transports vesicles containing the N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites.
KIF3B is also known as FLA8, HH0048, KLP-11, OTSC12, RP89.
