KHK

Description

The KHK gene encodes for ketohexokinase, an enzyme that plays a crucial role in carbohydrate metabolism. It catalyzes the phosphorylation of fructose to fructose-6-phosphate, a key step in both glycolysis and gluconeogenesis. This enzyme is particularly important in the liver, where it contributes to the regulation of blood glucose levels and the conversion of fructose into energy. KHK gene variations have been linked to various metabolic disorders and are currently being investigated as potential therapeutic targets.

Associated Diseases

• Nonalcoholic fatty liver disease (NAFLD)
• Metabolic syndrome
• Type 2 diabetes
• Hypertriglyceridemia
• Fructose intolerance
• Obesity

Did you know?

The KHK gene is highly polymorphic, meaning there are many variations in its sequence. These variations can influence the enzyme‘s activity and may contribute to individual differences in metabolic responses.