KCNH1
Description
The KCNH1 (potassium voltage-gated channel subfamily H member 1) is a protein-coding gene located on chromosome 1.
The KCNH1 gene encodes a potassium channel protein crucial for regulating various cellular functions, including neurotransmitter release, heart rate, and cell growth. This protein forms a pore in the cell membrane, allowing potassium ions to pass through, impacting electrical signals within cells. It is particularly active in brain and muscle cells, and its overexpression can promote cancer cell growth. Two different versions of the protein can be produced due to alternative splicing of the gene. KCNH1 interacts with another protein called KCNB1, and its function is primarily to regulate the flow of potassium ions across cell membranes.
KCNH1 is a pore-forming alpha subunit of a voltage-gated delayed rectifier potassium channel, responsible for mediating IK(NI) current in myoblasts. Its channel properties are modulated by subunit assembly, and it plays a role in regulating cell proliferation and differentiation, particularly adipogenic and osteogenic differentiation in mesenchymal stem cells.
KCNH1 is also known as EAG, EAG1, K(V)10.1, Kv10.1, TMBTS, ZLS1, h-eag, hEAG, hEAG1.
