KANK2 : KN motif and ankyrin repeat domains 2
Description
The KANK2 (KN motif and ankyrin repeat domains 2) is a protein-coding gene located on chromosome 19.
The KANK2 gene provides instructions for making a protein called SIP, which regulates steroid receptor coactivators (SRCs). SIP binds to SRCs in the cytoplasm, preventing them from entering the nucleus and activating genes, thereby controlling gene activity. SIP is found in many organs and tissues, including the skin and kidneys, but its specific roles in these areas are not fully understood.
KANK2 protein is involved in the regulation of gene transcription by sequestering nuclear receptor coactivators such as NCOA1, NCOA2, and NCOA3 in the cytoplasm. It also regulates caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can trigger the degradation of KANK2, allowing AIFM1 to translocate to the nucleus and induce apoptosis. Additionally, KANK2 negatively regulates vitamin D receptor signaling. KANK2 interacts with ARHGDIA, influencing the formation of actin stress fibers and regulating the Rho signaling pathway. This involvement in the Rho pathway suggests a role for KANK2 in cell adhesion, migration, and proliferation. Specifically, KANK2 has been shown to regulate podocyte migration during kidney development.
KANK2 is also known as ANKRD25, MXRA3, NPHS16, PPKWH, SIP.
