IREB2

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Description

IREB2 (Iron Regulatory Element Binding Protein 2) is a vital protein involved in iron homeostasis. It functions as a key regulator of iron metabolism, ensuring a delicate balance between iron absorption, storage, and utilization. IREB2 interacts with iron-responsive elements (IREs) located on the 5‘ untranslated region (UTR) of mRNAs encoding proteins associated with iron metabolism, such as ferritin and transferrin receptor 1 (TfR1). When cellular iron levels are low, IREB2 binds to IREs, stabilizing the mRNA and promoting the synthesis of proteins that enhance iron uptake (like TfR1). Conversely, when iron levels are high, IREB2 detaches from IREs, allowing the degradation of mRNAs involved in iron uptake, while promoting the synthesis of iron storage proteins (like ferritin). This intricate interplay between IREB2 and IREs ensures that cells maintain the appropriate iron levels essential for various cellular processes.

Associated Diseases

• Iron deficiency anemia
• Iron overload disorders (e.g., hemochromatosis)
• Neurodevelopmental disorders (e.g., autism spectrum disorder)

Did you know?

IREB2 is expressed in various tissues throughout the body, playing a crucial role in maintaining iron homeostasis at the cellular level.