IQSEC1
Description
The IQSEC1 (IQ motif and Sec7 domain ArfGEF 1) is a protein-coding gene located on chromosome 3.
IQSEC1, also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa), is a protein involved in signal transduction. It functions as a guanine nucleotide exchange factor (GEF) that promotes the binding of GTP to the ADP ribosylation factor proteins ARF6, ARF1, and ARF5. This activation triggers the ADP-ribosylation activity of the target protein and leads to modification of its substrates. IQSEC1, through its activation of ARF6, plays a key role in regulating various cellular processes, including endocytosis of plasma membrane proteins, E-cadherin recycling, and actin cytoskeleton remodeling. It is particularly important in regulating cell adhesion, with lower levels of IQSEC1 resulting in enhanced cell spreading and attachment.
IQSEC1 acts as a guanine nucleotide exchange factor (GEF) for ARF1 and ARF6, enhancing their GTP binding activity. This activity is further stimulated by lipid binding. IQSEC1 is specifically involved in mediating the internalization of beta-1 integrin through its GEF activity on ARF6. It plays a probable role in neuronal development, influencing vesicle formation by endocytoc cargo. In long-term depression, IQSEC1 interacts with GRIA2, triggering the activation of ARF6 to internalize synaptic AMPAR receptors.
IQSEC1 is also known as ARF-GEP100, ARFGEP100, BRAG2, GEP100, IDDSSBA.
