IMPA1
Description
The IMPA1 (inositol monophosphatase 1) is a protein-coding gene located on chromosome 8.
IMPA1 (Inositol monophosphatase 1) is an enzyme encoded by the IMPA1 gene in humans. It interacts with Bergmann glial S100B and calbindin. IMPA1 is inhibited by L-690,330 and L-690,488, which can alter phosphoinositide signaling, autophagy, apoptosis, and other cellular processes. IMPA1 was initially thought to be involved in bipolar disorder due to the shared mechanism of action of lithium, carbamazepine, and valproic acid, but this hypothesis has not been fully confirmed.
IMPA1 is responsible for providing inositol, which is necessary for the synthesis of phosphatidylinositol and polyphosphoinositides. It has been implicated as the pharmacological target for lithium action in the brain. IMPA1 displays broad substrate specificity and can utilize myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
IMPA1 is also known as IMP, IMPA, MRT59.
