IL36RN : interleukin 36 receptor antagonist
Description
The IL36RN (interleukin 36 receptor antagonist) is a protein-coding gene located on chromosome 2.
The IL36RN gene provides instructions for making a protein called interleukin 36 receptor antagonist (IL-36Ra). This protein is primarily found in the skin where it helps regulate inflammation, part of the body's early immune response. Inflammation in the skin is stimulated when other proteins called IL-36 alpha (α), IL-36 beta (β), or IL-36 gamma (γ) attach to (bind) a specific receptor protein. This binding turns on (activates) signaling pathways that promote inflammation, namely the NF-κB and MAPK pathways. To control inflammatory reactions, the IL-36Ra protein binds to the receptor protein so that IL-36α, IL-36β, and IL-36γ cannot. In this way, the IL-36Ra protein blocks (antagonizes) the receptor's activity.
IL-36RN inhibits the activity of interleukin-36 (IL36A, IL36B, and IL36G) by binding to the receptor IL1RL2 and blocking its association with the coreceptor IL1RAP. This prevents the activation of signaling pathways that promote inflammation. IL-36RN is part of the IL-36 signaling system, which is believed to be present in epithelial barriers and participate in local inflammatory responses. This system shares similarities with the IL-1 system, with which it shares the coreceptor. IL-36RN is thought to play a role in skin inflammation and may be involved in the innate immune response to fungal pathogens like Aspergillus fumigatus. It may also activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
IL36RN is also known as FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14.
