IL1RN
Description
The IL1RN (interleukin 1 receptor antagonist) is a protein-coding gene located on chromosome 2.
IL1RN encodes the interleukin-1 receptor antagonist (IL-1RA) protein, which is a natural inhibitor of the pro-inflammatory effects of IL1B. IL-1RA binds to the same receptor as IL1, preventing IL1 from signaling the cell. This helps to modulate immune and inflammatory responses. Mutations in IL1RN can lead to a rare autoinflammatory disease called deficiency of the interleukin-1–receptor antagonist (DIRA). Polymorphisms in IL1RN have also been linked to an increased risk of certain conditions, such as osteoporotic fractures and gastric cancer.
IL1RN is also known as CRMO2, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4.
