IL17RA
Description
The IL17RA (interleukin 17 receptor A) is a protein-coding gene located on chromosome 22.
Interleukin 17 receptor A (IL17RA, CDw217) is a human gene. It encodes a ubiquitous type I membrane glycoprotein that binds to interleukin 17A (IL17A), a proinflammatory cytokine secreted by activated T-lymphocytes. IL17A is a potent inducer of neutrophil maturation from hematopoietic precursors. IL17A and its receptor play a pathogenic role in inflammatory and autoimmune diseases like rheumatoid arthritis. IL17RA is likely multimeric.
IL17RA is a receptor for IL17A and IL17F, key cytokines in innate and adaptive immunity, crucial for antimicrobial defense and tissue integrity. It binds IL17A with higher affinity than IL17F and forms complexes with IL17RC, enabling binding of IL17A and IL17F homodimers and heterodimers. Upon cytokine binding, IL17RA interacts with TRAF3IP2, activating NF-kappa-B and MAPkinase pathways, leading to the production of pro-inflammatory mediators like cytokines, chemokines, and antimicrobial peptides. IL17RA plays a role in neutrophil activation and recruitment during infection, contributing to the destruction of bacteria and fungi. It also promotes germinal center formation in secondary lymphoid organs by regulating B cell chemotaxis and enhancing their somatic hypermutation. IL17RA contributes to the maintenance of epithelial barrier integrity during homeostasis and infection, stimulating the production of antimicrobial beta-defensins. It also participates in antiviral defense, enhancing immunity against West Nile virus and promoting Influenza virus clearance. IL17RA also binds IL17C as part of a complex with IL17RE.
IL17RA is also known as CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R.
