IHH

Description

The IHH gene, also known as Indian hedgehog, plays a vital role in skeletal development. It encodes a signaling protein that is essential for chondrocyte differentiation and bone formation. IHH is expressed in the growth plate of long bones, where it regulates the proliferation and maturation of chondrocytes. This complex signaling pathway ensures proper bone growth and development.

Associated Diseases

• Achondroplasia
• Thanatophoric dysplasia
• SADDAN syndrome
• Langer-Giedion syndrome
• Diastrophic dysplasia
• Ellis-van Creveld syndrome

Did you know?

The IHH gene gets its name from the fact that it was initially identified in a mutant fruit fly with a hedgehog-like appearance.