IGF2R
Description
The IGF2R (insulin like growth factor 2 receptor) is a protein-coding gene located on chromosome 6.
IGF2R, also known as the cation-independent mannose-6-phosphate receptor (CI-MPR), is a protein that plays a crucial role in the transport of lysosomal enzymes and the regulation of IGF2 signaling. It is a type I transmembrane protein with a large extracellular domain containing 15 repeats homologous to the mannose 6-phosphate receptor. One of these repeats binds IGF2, while two others bind mannose-6-phosphate. IGF2R facilitates the transport of lysosomal enzymes from the Golgi apparatus to lysosomes by binding to mannose-6-phosphate tagged lysosomal enzymes and transporting them to the lysosome. It also binds IGF2 at the cell surface and internalizes it, reducing IGF2 signaling.
IGF2R facilitates the movement of phosphorylated lysosomal enzymes from the Golgi apparatus and the cell surface to lysosomes. Lysosomal enzymes with phosphomannosyl residues specifically attach to mannose-6-phosphate receptors within the Golgi, forming a receptor-ligand complex. This complex is then transported to an acidic prelysosomal compartment, where the low pH causes the complex to dissociate. Subsequently, the receptor is recycled back to the Golgi for further trafficking through its interaction with the retromer. IGF2R also binds IGF2 and acts as a positive regulator of T-cell coactivation by binding DPP4.
IGF2R is also known as CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI.
