IGF1R

Description

The IGF1R gene, encoding the insulin-like growth factor 1 receptor, plays a pivotal role in regulating cell growth, proliferation, and survival. It is a transmembrane receptor tyrosine kinase that binds to insulin-like growth factors (IGFs), triggering intracellular signaling cascades that promote cell growth and development. IGF1R signaling is crucial during fetal development, and its dysregulation has been implicated in various diseases, including cancer and metabolic disorders.

Associated Diseases

• Cancer (e.g., breast cancer, colorectal cancer, prostate cancer)
• Acromegaly (excessive growth hormone production)
• Diabetes
• Metabolic Syndrome
• Neurodegenerative diseases

Did you know?

IGF1R is a target for several cancer therapies, with drugs designed to inhibit its activity.