IGF1
Insulin-like Growth Factor 1 (IGF1): A Versatile Growth Factor with Diverse Roles
Description
Insulin-like growth factor 1 (IGF1), also known as somatomedin C, is a polypeptide hormone that plays a crucial role in growth and development. It is structurally similar to insulin but has distinct biological functions. IGF1 is primarily synthesized by the liver in response to growth hormone (GH) produced by the pituitary gland.
Associated Diseases
IGF1 is involved in regulating various physiological processes, and its dysregulation can contribute to several diseases and conditions:
- Acromegaly and Gigantism: Excessive production of IGF1 can lead to acromegaly (enlargement of hands, feet, and jaw) and gigantism (excessive height).
- Beckwith-Wiedemann Syndrome: An overgrowth disorder associated with increased IGF1 levels.
- Cancer: IGF1 can promote cell proliferation and survival, making it a potential target for cancer therapies.
- Type 2 Diabetes: Impaired IGF1 signaling has been linked to insulin resistance and type 2 diabetes.
- Aging: IGF1 levels decline with age, contributing to age-related decline in muscle mass and strength.
Did you Know ?
Studies have shown that individuals with high IGF1 levels in adulthood have an increased risk of developing certain cancers, such as prostate cancer and breast cancer.
