IFT88
Description
The IFT88 (intraflagellar transport 88) is a protein-coding gene located on chromosome 13.
IFT88 is a protein encoded by the IFT88 gene. It belongs to the tetratrico peptide repeat (TPR) family of proteins. Mutations in a similar gene in mice can lead to polycystic kidney disease. Two different forms of the IFT88 protein have been identified. In 2012, a mutation in the IFT88 gene was found to be responsible for a new type of ciliopathy and anosmia in humans. This condition can be treated in mice using gene therapy. IFT88 has been shown to interact with the proteins BAT2 and WDR62. WDR62 is required for the proper localization of IFT88 to the base and shaft of cilia.
IFT88 positively regulates the formation of primary cilia, which are hair-like structures that play important roles in cell signaling and development. IFT88 is also involved in autophagy, a process where cells break down and recycle cellular components. It is required for the movement of ATG16L, a protein involved in autophagy, and for the expansion of the autophagic compartment.
IFT88 is also known as D13S1056E, DAF19, TG737, TTC10, hTg737.
