IFT122 : intraflagellar transport 122
Description
The IFT122 (intraflagellar transport 122) is a protein-coding gene located on chromosome 3.
The IFT122 gene provides instructions for making a protein that helps build and maintain cilia, tiny hair-like structures on cells. Cilia are involved in cell communication and are vital for many tissues, including the kidneys, liver, and the eye's light-sensitive part. They also play a role in bone development, though the exact mechanism isn't fully understood. IFT122 is part of a complex called IFT-A, which is crucial for moving substances within cilia. This complex carries materials from the tip of the cilia to the base. The IFT-A complex also plays a key role in regulating the Sonic Hedgehog signaling pathway, which controls cell growth and development.
The IFT122 protein is essential for the formation and function of cilia, which are tiny hair-like structures on the surface of cells. It plays a role in moving materials within cilia, a process called intraflagellar transport. This protein is part of a complex called IFT-A, which is involved in carrying materials from the tip of cilia to their base. IFT122 is also important for regulating the Sonic Hedgehog signaling pathway, which controls cell growth and development. It is also required to recruit TULP3 to primary cilia, which are a type of cilia found on many cells.
IFT122 is also known as CED, CED1, CFAP80, FAP80, SPG, WDR10, WDR10p, WDR140.
