HPD : 4-hydroxyphenylpyruvate dioxygenase

Description

The HPD gene encodes for the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which plays a critical role in prostaglandin metabolism. Prostaglandins are lipid signaling molecules involved in various physiological processes, including inflammation, pain, and blood pressure regulation. HPGD catalyzes the conversion of prostaglandins to inactive metabolites, effectively reducing their signaling activity. Variations or mutations in the HPD gene can disrupt this process, potentially leading to altered prostaglandin levels and associated health implications.

Associated Diseases

• Cancer (e.g., colorectal cancer, breast cancer)
• Inflammation (e.g., arthritis, inflammatory bowel disease)
• Cardiovascular disease (e.g., hypertension, atherosclerosis)
• Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)

Did you know?

HPGD activity is influenced by dietary factors, including consumption of omega-3 fatty acids, which are known to have anti-inflammatory effects.