HPCA
Description
The HPCA gene, also known as histone chaperone A, plays a crucial role in the regulation of cell division. It acts as a molecular escort, ensuring that histones, the protein building blocks of DNA, are correctly assembled into nucleosomes. This process is essential for proper DNA replication and repair. HPCA is highly conserved across species, highlighting its fundamental importance in cellular processes.
Associated Diseases
- Cancer: Aberrant HPCA expression has been linked to various cancers, including breast cancer, lung cancer, and colon cancer.
- Neurological disorders: Mutations in the HPCA gene have been associated with developmental disorders affecting the nervous system, such as intellectual disability and epilepsy.
Did you know?
HPCA is also involved in the regulation of gene expression, suggesting it plays a multifaceted role in the nucleus.
