HOXA2

Description

The HOXA2 gene plays a crucial role in embryonic development, particularly in the formation of the head and neck. It acts as a transcription factor, controlling the expression of other genes involved in these processes. Mutations in HOXA2 can lead to a range of developmental defects, including craniofacial abnormalities and neurological disorders. This gene‘s importance extends beyond embryogenesis, as it is also implicated in the regulation of adult tissue homeostasis and the development of certain cancers.

Associated Diseases

• Hand-Foot-Genital Syndrome (HFGS)
• Synpolydactyly
• Craniofacial abnormalities
• Neurological disorders
• Cancer (e.g., leukemia, lymphoma)
• Congenital heart defects

Did you know?

HOXA2 is one of the earliest genes to be expressed during embryonic development, highlighting its fundamental role in establishing the body plan.