HHAT
Description
The HHAT gene, also known as the Hedgehog acyltransferase gene, plays a crucial role in cholesterol metabolism by encoding the HHAT enzyme. This enzyme is responsible for attaching a fatty acid chain to cholesterol, converting it into a modified form called 24S-hydroxycholesterol. This process is essential for the proper functioning of various cellular processes, including Hedgehog signaling, which is involved in embryonic development and tissue regeneration. Disruptions in HHAT gene function can lead to several health issues, highlighting its importance in maintaining overall health.
Associated Diseases
Did you know?
HHAT was originally identified as a key regulator of the Hedgehog signaling pathway, a crucial pathway involved in embryonic development.
