HERC1
Description
The HERC1 gene, located on chromosome 15, encodes a massive protein known as HERC1. This protein acts as a ubiquitin ligase, a molecular machine responsible for attaching ubiquitin tags to other proteins. Ubiquitination is a crucial cellular process that controls a wide array of functions, including protein degradation, signal transduction, and DNA repair. HERC1‘s intricate network of interactions makes it a central player in maintaining cellular homeostasis and protecting against various diseases.
Associated Diseases
- Hereditary Sensory and Autonomic Neuropathy Type 1 (HSAN1)
- Oculomotor Apraxia-2 (OMIM #614919)
- Parkinson‘s Disease
- Cancer (various types)
- Alzheimer‘s Disease
Did you know?
HERC1 is one of the largest known human genes, spanning over 1 million base pairs!
