GSTZ1

Description

The GSTZ1 gene, located on chromosome 14q24.3, encodes for the enzyme glutathione S-transferase zeta 1. This enzyme plays a crucial role in detoxification processes by catalyzing the conjugation of glutathione, a tripeptide with antioxidant properties, to various electrophilic compounds, including carcinogens, drugs, and environmental toxins. This conjugation reaction reduces the toxicity and facilitates the elimination of these compounds from the body. GSTZ1 is predominantly expressed in the liver, the primary organ involved in detoxification, but its expression has also been detected in other tissues like the kidneys, lungs, and brain.

Associated Diseases

• Increased risk of cancer, particularly lung and bladder cancer
• Neurodegenerative diseases like Alzheimer‘s and Parkinson‘s
• Drug resistance in cancer chemotherapy
• Liver diseases and toxicity

Did you know?

Genetic variations in the GSTZ1 gene have been associated with individual susceptibility to environmental toxins and cancer risk.