GSTP1
Description
The GSTP1 (glutathione S-transferase pi 1) is a protein-coding gene located on chromosome 11.
GSTP1 is a human gene that encodes glutathione S-transferase P, an enzyme crucial for detoxification. GSTP1 belongs to the GST family, which catalyzes the conjugation of hydrophobic and electrophilic compounds with glutathione. There are four main classes of GSTs: alpha, mu, pi, and theta. GSTP1 is polymorphic, meaning it exists in different variants that can influence its activity and affect susceptibility to various diseases, including cancer. GSTP1 interacts with proteins like Fanconi anemia, complementation group C and MAPK8. It is expressed in many tissues, notably the biliary tree, renal distal convoluted tubules, and lungs. Triple-negative breast cancer cells rely on GSTP1, making it a potential drug target. Piperlongumine has been identified as a potential inhibitor of GSTP1.
GSTP1 catalyzes the conjugation of reduced glutathione to a wide range of hydrophobic and electrophilic compounds, both exogenous and endogenous. This includes the formation of glutathione conjugates for prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PMID:9084911), and the production of novel hepoxilin regioisomers (PMID:21046276). GSTP1 also plays a role in preventing neurodegeneration by negatively regulating CDK5 activity through the translocation of p25/p35. (PMID:21046276, PMID:21668448, PMID:9084911)
GSTP1 is also known as DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI.
