GSR

Description

The GSR gene (Glutathione Reductase) provides instructions for making the enzyme glutathione reductase. This enzyme is vital for maintaining the body‘s antioxidant defense system. Glutathione reductase converts oxidized glutathione (GSSG) back to its reduced form (GSH), a critical step in protecting cells from damage caused by reactive oxygen species (ROS). ROS are byproducts of normal metabolism that can damage DNA, proteins, and lipids, leading to various health problems. The GSR gene plays a crucial role in maintaining a balance between reduced and oxidized glutathione, ensuring the proper functioning of the antioxidant defense system.

Associated Diseases

• Oxidative stress-related diseases (e.g., cancer, cardiovascular disease, neurodegenerative disorders)
• G6PD deficiency (a genetic disorder that affects red blood cell function)
• Drug-induced hemolytic anemia

Did you know?

GSR enzyme activity is influenced by various factors, including nutrition, exercise, and exposure to environmental toxins.