GRIK2
Description
The GRIK2 gene encodes the GluK2 subunit of the kainate receptor, a type of ionotropic glutamate receptor that plays a crucial role in synaptic transmission and neuronal plasticity. These receptors are widely expressed throughout the brain, particularly in the hippocampus, cortex, and cerebellum, and are involved in various cognitive functions, including learning, memory, and synaptic plasticity. The GluK2 subunit contributes to the assembly and function of kainate receptors, modulating their channel properties and influencing their response to glutamate. Genetic variations in GRIK2 have been linked to various neurological disorders, highlighting its importance in brain health.
Associated Diseases
Did you know?
GRIK2 is one of the few genes that has been implicated in both autism spectrum disorder and schizophrenia, highlighting the complex interplay between genetic factors and neurodevelopmental disorders.
