GPNMB
Description
GPNMB, also known as osteoblast-specific factor 2 (OSF-2), is a transmembrane glycoprotein widely expressed in various tissues, including bone, skin, and immune cells. It plays crucial roles in cell adhesion, migration, and signaling. GPNMB interacts with extracellular matrix components and participates in pathways involving growth factors, cytokines, and immune responses. Its diverse functions highlight its significance in normal development and disease pathogenesis.
Associated Diseases
- Cancer (melanoma, breast cancer, lung cancer)
- Osteoporosis
- Inflammatory diseases (rheumatoid arthritis, inflammatory bowel disease)
- Neurodegenerative diseases (Alzheimer‘s disease, Parkinson‘s disease)
- Cardiovascular diseases
Did you know?
GPNMB‘s expression is regulated by vitamin D, suggesting a potential link between vitamin D deficiency and certain GPNMB-related diseases.
