GP1BA : glycoprotein Ib platelet subunit alpha
Description
The GP1BA (glycoprotein Ib platelet subunit alpha) is a protein-coding gene located on chromosome 17.
The GP1BA gene provides instructions for making glycoprotein Ib-alpha (GPIbα), a subunit of the GPIb-IX-V complex found on platelets. This complex is essential for blood clotting, as it binds to von Willebrand factor (vWF) on the blood vessel wall, enabling platelets to stick to the injury site. GPIbα is crucial for the assembly of the GPIb-IX-V complex and its interaction with vWF, triggering blood clotting. It also interacts with other clotting proteins, contributing to further steps in the clotting process.
GP1BA is also known as BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, GPIbalpha, VWDP.
Associated Diseases
- Bernard-Soulier syndrome
- Nonarteritic anterior ischemic optic neuropathy, susceptibility to
- Pseudo-Von willebrand disease
- Bernard-Soulier syndrome, type A2, autosomal dominant
- Fetal and neonatal alloimmune thrombocytopenia
