GLRB
Description
The GLRB (glycine receptor beta) is a protein-coding gene located on chromosome 4.
The GLRB gene encodes the glycine receptor subunit beta protein, which is involved in forming the inhibitory glycine receptor in the central nervous system. This receptor is a pentameric complex composed of alpha (GLRA1, GLRA2) and beta subunits, and it mediates postsynaptic inhibition in the spinal cord and other brain regions.
Glycine receptors are ligand-gated chloride channels that open in response to glycine binding. GLRB, also known as the 58 kDa glycine receptor subunit, does not form functional channels on its own but plays a crucial role in forming heteromeric channels with other glycine receptor subunits (GLRA1, GLRA2, and GLRA3). These heteromeric channels are responsible for mediating inhibitory postsynaptic currents and regulating neuronal excitability. Interestingly, GLRB-containing channels exhibit increased sensitivity to glycine compared to channels composed solely of GLRA1 subunits.
GLRB is also known as HKPX2.
