GALNT2
Description
The GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2) is a protein-coding gene located on chromosome 1.
The GALNT2 gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family of enzymes transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue, initiating the process of O-linked oligosaccharide biosynthesis. GALNT2 is primarily located in the trans-Golgi. Individual GalNAc-transferases have unique activities, and the initiation of O-glycosylation in a cell is regulated by a diverse set of GalNAc-transferases.
GALNT2 catalyzes the initial step in O-linked oligosaccharide biosynthesis by transferring an N-acetyl-D-galactosamine residue to a serine or threonine residue on a protein receptor. This enzyme has a broad range of substrate peptides, including EA2, Muc5AC, Muc1a, and Muc1b. It is likely involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region and has been implicated in the O-linked glycosylation of APOC-III, ANGPTL3, and PLTP. GALNT2 participates in the regulation of HDL-C metabolism.
GALNT2 is also known as CDG2T, GalNAc-T2.
