GALM
Description
GALM, or UDP-galactose 4-epimerase, is an enzyme responsible for catalyzing the reversible interconversion of UDP-galactose and UDP-glucose. This crucial reaction is a key step in galactose metabolism, allowing the body to utilize galactose, a sugar found in dairy products and other foods, for energy production. The GALM gene provides instructions for making this enzyme, and its proper functioning is essential for maintaining normal galactose metabolism.
Associated Diseases
- Galactosemia: A rare genetic disorder caused by mutations in the GALM gene, leading to a deficiency in GALM activity. This deficiency results in the accumulation of galactose in the blood, causing a range of health problems, including liver damage, kidney failure, and mental retardation.
- Other Metabolic Disorders: While galactosemia is the most prominent associated disease, mutations in the GALM gene can also contribute to other metabolic disorders, though these connections are less well understood.
Did you know?
GALM is also involved in the biosynthesis of certain glycoproteins and glycolipids, essential components of cell membranes and other biological structures.
