FUT6
Description
The FUT6 gene provides instructions for producing an enzyme called alpha(1,6)-fucosyltransferase. This enzyme plays a critical role in glycosylation, the process of attaching sugar molecules (glycans) to proteins and lipids. Glycosylation is essential for various cellular functions, including cell signaling, immune response, and protein folding. FUT6, specifically, adds a fucose sugar to certain glycans, impacting their structure and function. Mutations in the FUT6 gene can disrupt this delicate process, leading to a range of health consequences.
Associated Diseases
- Cancer: Mutations in FUT6 have been linked to increased risk and progression of various cancers, including colorectal, breast, and lung cancer.
- Immune disorders: Altered FUT6 expression and activity have been implicated in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
- Inflammatory bowel disease (IBD): FUT6 plays a role in intestinal inflammation and has been associated with IBD development.
- Neurological disorders: Studies suggest a connection between FUT6 and neurological disorders, particularly Alzheimer‘s disease.
Did you know?
The FUT6 gene is highly polymorphic, meaning there are many variations in its sequence among individuals. These variations can influence the activity of the FUT6 enzyme and contribute to differences in disease susceptibility.
