FRAS1 : Fraser extracellular matrix complex subunit 1
Description
The FRAS1 (Fraser extracellular matrix complex subunit 1) is a protein-coding gene located on chromosome 4.
The FRAS1 gene provides instructions for making a protein that is part of a group of proteins called the FRAS/FREM complex. This complex is found in basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. The FRAS/FREM complex is particularly important during development before birth. One of its roles is to anchor the top layer of skin by connecting the basement membrane of the top layer to the layer of skin below. The FRAS/FREM complex is also involved in the proper development of certain other organs and tissues, including the kidneys, although the mechanism is unclear.
The FRAS1 protein is involved in the organization of the extracellular matrix, a network of molecules that provides structural support and helps regulate cellular activity. It plays a crucial role in maintaining the adhesion between the epidermis (outer layer of skin) and the basement membrane, a thin layer that separates the epidermis from the underlying tissues. This adhesion is essential for proper organ development during embryonic growth. Additionally, FRAS1 is linked to the organization and function of the brain.
FRAS1 is also known as FRASRS1.
