FMN2
Description
The FMN2 (formin 2) is a protein-coding gene located on chromosome 1.
FMN2 is an actin-binding protein involved in the assembly and reorganization of the actin cytoskeleton (PubMed:22330775, PubMed:21730168). It acts as an actin nucleation factor and promotes the assembly of actin filaments in conjunction with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). FMN2 is involved in intracellular vesicle transport along actin fibers, linking actin cytoskeleton dynamics with intracellular transport (By similarity). It is required for asymmetric spindle positioning, asymmetric oocyte division, and polar body extrusion during female germ cell meiosis (By similarity). FMN2 plays a role in responses to DNA damage, cellular stress, and hypoxia by protecting CDKN1A from degradation, thereby contributing to stress-induced cell cycle arrest (PubMed:23375502). In the nucleus, it collaborates with SPIRE1 and SPIRE2 to assemble nuclear actin filaments in response to DNA damage, facilitating the movement of chromatin and repair factors after DNA damage (PubMed:26287480). FMN2 protects cells from apoptosis by safeguarding CDKN1A from degradation (PubMed:23375502). (ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480)
FMN2 is also known as -.
