FLVCR1

Description

The FLVCR1 (FLVCR choline and heme transporter 1) is a protein-coding gene located on chromosome 1.

FLVCR1, also known as Feline leukemia virus subgroup C receptor-related protein 1, is a protein encoded by the FLVCR1 gene (SLC49A1) in humans.

FLVCR1 mediates heme efflux from the cytoplasm to the extracellular compartment, requiring the presence of HPX to maintain intracellular free heme balance and protect cells from heme toxicity. This heme export safeguards against heme or ferrous iron toxicities in various tissues, including the liver, brain, sensory neurons, and during erythropoiesis, a process with intensified heme synthesis. FLVCR1 might also export coproporphyrin and protoporphyrin IX, intermediates in the heme biosynthetic pathway, but does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral, or coupled to other ions, remains unclear.

FLVCR1 is also known as AXPC1, FLVCR, MFSD7B, PCA, PCARP, SLC49A1.

Associated Diseases

• Ataxia, posterior column, with retinitis pigmentosa
• Posterior column ataxia-retinitis pigmentosa syndrome