FBXO7
Description
The FBXO7 (F-box protein 7) is a protein-coding gene located on chromosome 22.
FBXO7, or F-box only protein 7, is a protein encoded by the FBXO7 gene in humans. Mutations in this gene have been linked to Parkinson's disease. FBXO7 is a member of the F-box protein family, known for their role in ubiquitin-mediated protein degradation. Specifically, FBXO7 is part of the SCF (SKP1-cullin-F-box) complex, which tags proteins for degradation by the proteasome. This protein likely plays a role in regulating hematopoiesis. It has been shown to interact with a number of proteins, including SKP1A, CUL1, CDK6, p27, PI31, Parkin, and PINK1.
FBXO7 is a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, which targets proteins for degradation by the proteasome. It plays a role in various biological processes such as cell cycle regulation, cell proliferation, and maintenance of chromosome stability. FBXO7 specifically recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. In the context of mitochondrial quality control, FBXO7 operates downstream of PINK1, promoting the clearance of damaged mitochondria through mitophagy by targeting PRKN to dysfunctional mitochondria. FBXO7 also promotes ubiquitination of MFN1. Furthermore, it mediates the ubiquitination and degradation of UXT isoform 2, leading to impairment of the NF-kappa-B signaling pathway. It inhibits NF-kappa-B by promoting the ubiquitination of TRAF2. FBXO7 influences the assembly and activity of the proteasome in cells, including neurons, by ubiquitinating the proteasomal subunit PSMA2 through Lys-63-linked polyubiquitin chains. It also promotes Lys-48-linked polyubiquitination of SIRT7, contributing to hydrogen peroxide-induced cell death.
FBXO7 is also known as FBX, FBX07, FBX7, PARK15, PKPS.
