FBP1

Description

The FBP1 gene encodes fructose-1,6-bisphosphatase 1 (FBP1), a critical enzyme involved in gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources. FBP1 catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, a crucial step in gluconeogenesis. This enzyme plays a vital role in maintaining blood glucose levels, particularly during periods of fasting or starvation.

Associated Diseases

• Type 2 Diabetes Mellitus: FBP1 dysfunction can contribute to insulin resistance and impaired glucose tolerance, increasing the risk of type 2 diabetes.
• Fatty Liver Disease: Altered FBP1 expression has been linked to the development of non-alcoholic fatty liver disease (NAFLD).
• Cancer: Some studies suggest that FBP1 dysregulation might be involved in the progression of certain cancers, such as colorectal cancer and hepatocellular carcinoma.
• Genetic Disorders: Rare genetic mutations in the FBP1 gene can lead to inherited metabolic disorders affecting glucose metabolism.

Did you know?

FBP1 activity is tightly regulated by hormones such as insulin and glucagon, reflecting its importance in maintaining glucose homeostasis.