FANCD2
Description
The FANCD2 gene plays a crucial role in DNA repair, specifically in the Fanconi anemia (FA) pathway. This pathway is essential for repairing interstrand crosslinks (ICLs), which are DNA damages caused by agents like chemotherapy drugs and environmental toxins. FANCD2 acts as a central player in this pathway, orchestrating the recruitment and activation of other repair proteins to the damaged site. Its function is critical for maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer.
Associated Diseases
Did you know?
Mutations in the FANCD2 gene are the most common cause of Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, developmental abnormalities, and an increased risk of cancer.
