FAN1

Description

FAN1, also known as Fanconi anemia, complementation group I, is a crucial DNA repair gene involved in multiple cellular processes. It plays a key role in maintaining genome stability by recognizing and removing various DNA lesions, including interstrand crosslinks (ICLs), double-strand breaks (DSBs), and stalled replication forks. FAN1's complex mechanisms involve both DNA cleavage and end-resection activities, contributing to the accurate repair of damaged DNA and preventing the accumulation of mutations. Furthermore, FAN1 has been implicated in various cellular processes, such as DNA replication, transcription, and telomere maintenance.

Associated Diseases

• Fanconi anemia (FA)
• Cancer (various types, including leukemia, breast cancer, and ovarian cancer)
• Neurodegenerative disorders
• Developmental defects

Did you know?

FAN1 was initially discovered in the context of Fanconi anemia (FA), a rare genetic disorder characterized by bone marrow failure, developmental abnormalities, and increased cancer susceptibility. FA patients often carry mutations in genes involved in DNA repair, including FAN1.