F10 : coagulation factor X
Description
The F10 gene, plays a vital role in the coagulation cascade, the complex series of steps that lead to blood clotting. It encodes for the protein known as factor X, a serine protease that acts as an enzyme, converting prothrombin into thrombin. This conversion is a crucial step in the formation of fibrin, a protein that forms the meshwork of a blood clot.
Associated Diseases
- Hemophilia B (Christmas disease): This is a bleeding disorder caused by a deficiency in factor IX, which works together with factor X in the coagulation cascade.
- Factor X deficiency: A rare inherited bleeding disorder caused by a mutation in the F10 gene, leading to a reduced or non-functional factor X protein.
- Venous thromboembolism (VTE): This includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Mutations in the F10 gene can increase the risk of VTE by promoting excessive clotting.
- Other clotting disorders: Factor X can be affected by other coagulation disorders, such as protein C deficiency and protein S deficiency.
Did you know?
Factor X is a key component of the "common pathway" of the coagulation cascade, which means it is involved in the final steps of clot formation, regardless of the initial trigger of the clotting process.
