ERBB3

Description

The ERBB3 gene provides instructions for making a protein called human epidermal growth factor receptor 3 (HER3). This protein is a receptor that sits on the surface of cells and plays a critical role in cell growth, differentiation, and survival. It does this by binding to growth factors like heregulin, triggering a cascade of signaling events within the cell. ERBB3 is a crucial component of the HER family of receptor tyrosine kinases, which are involved in various physiological processes, including embryonic development, tissue homeostasis, and wound healing. While ERBB3 is essential for normal cellular functions, its dysregulation can lead to various diseases.

Associated Diseases

• Cancer (breast, lung, ovarian, colorectal, gastric, prostate, etc.)
• Neurological disorders (Alzheimer‘s disease)
• Cardiovascular diseases (heart failure)

Did you know?

ERBB3 is unique among HER family members because it lacks intrinsic tyrosine kinase activity. It relies on other HER receptors, like HER2, for signaling.