EDAR : ectodysplasin A receptor

Description

The EDAR gene, plays a crucial role in the development of various tissues, including skin, hair, teeth, and sweat glands. It encodes a protein called ectodysplasin A receptor, which acts as a signaling molecule involved in cell-cell communication during embryonic development. Mutations in the EDAR gene can lead to a range of disorders affecting these tissues. This article explores the significance of the EDAR gene, its associated diseases, recent research findings, and potential avenues for improvement.

Associated Diseases

• Hypohidrotic ectodermal dysplasia (HED)
• Tooth agenesis
• Sparse hair
• Sweat gland dysfunction
• Ectodermal dysplasia syndromes
• Cleft lip and palate (rare cases)

Did you know?

A specific variation in the EDAR gene, known as EDAR370A, is associated with thicker hair, more sweat glands, and a lower risk of cleft lip and palate in East Asian populations.