DNAH8

Description

The DNAH8 gene provides instructions for making a protein called dynein heavy chain 8. This protein is a component of the dynein motor complex, which is essential for the movement of cilia and flagella. Cilia are hair-like structures found on the surface of many cells, and they play important roles in various cellular processes, including sensory perception, fluid transport, and cell signaling. Flagella are longer, whip-like structures that enable sperm cells to swim. Mutations in the DNAH8 gene can disrupt the function of the dynein motor complex, leading to a variety of human diseases.

Associated Diseases

• Primary ciliary dyskinesia (PCD)
• Kartagener syndrome
• Situs inversus
• Infertility
• Bronchiectasis
• Chronic sinusitis
• Respiratory distress syndrome

Did you know?

Mutations in DNAH8 are responsible for about 50% of all cases of primary ciliary dyskinesia.