DNAH11
Description
The DNAH11 (dynein axonemal heavy chain 11) is a protein-coding gene located on chromosome 7.
DNAH11, encoded by the DNAH11 gene in humans, is a member of the dynein heavy chain family. It acts as a microtubule-dependent motor ATPase protein, playing a crucial role in ciliary movement. This protein is associated with various physiological processes, including the movement of respiratory cilia, sperm motility, and the establishment of the adult body plan. While DNAH11's importance in embryonic development has been recognized, a knockout model of this gene has yet to be reported. During embryonic gastrulation, the primitive node, a structure responsible for body plan asymmetry, possesses motile cilia on its surface. These cilia are critical for directing nodal, a signaling molecule, towards the left side of the developing embryo, establishing left-right asymmetry. Therefore, proper expression of DNAH11 is essential for the correct establishment and subsequent development of the asymmetrical body plan.
DNAH11 is also known as CILD7, DNAHBL, DNAHC11, DNHBL, DPL11.
