DHPS
Description
The DHPS gene, located on chromosome 4, encodes for dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. DHFR catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF), a crucial cofactor for numerous metabolic pathways, including DNA synthesis, purine and pyrimidine synthesis, and amino acid metabolism. DHFR‘s role is paramount in cell growth and division, making it a target for various anticancer drugs. The DHPS gene exhibits variations in its sequence, leading to different enzyme activities and potentially impacting folate metabolism. Understanding these variations is crucial for both understanding genetic predispositions to diseases and developing targeted therapies.
Associated Diseases
Did you know?
The DHPS gene is highly conserved across species, indicating its essential role in life.
